منابع مشابه
N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer.
According to accepted doctrine, agonist-bound G protein-coupled receptors catalyze the exchange of GDP for GTP and facilitate the dissociation of Galpha and Gbetagamma, which in turn regulate their respective effectors. More recently, the existence of preformed signaling complexes, which may include receptors, heterotrimeric G proteins, and/or effectors, is gaining acceptance. We show herein th...
متن کاملAdenylyl cyclase type 5 in cardiac disease, metabolism, and aging.
G protein-coupled receptor/adenylyl cyclase (AC)/cAMP signaling is crucial for all cellular responses to physiological and pathophysiological stimuli. There are nine isoforms of membrane-bound AC, with type 5 being one of the two major isoforms in the heart. Since the role of AC in the heart in regulating cAMP and acute changes in inotropic and chronotropic state are well known, this review wil...
متن کاملType 5 adenylyl cyclase disruption leads to enhanced exercise performance
The most important physiological mechanism mediating enhanced exercise performance is increased sympathetic, beta adrenergic receptor (β-AR), and adenylyl cyclase (AC) activity. This is the first report of decreased AC activity mediating increased exercise performance. We demonstrated that AC5 disruption, that is, knock out (KO) mice, a longevity model, increases exercise performance. Important...
متن کاملNovel Modulation of Adenylyl Cyclase Type 2
Conley, Jason M. Ph.D., Purdue University, December 2013. Novel Modulation of Adenylyl Cyclase Type 2. Major Professor: Val J. Watts. Adenylyl cyclase isoforms are distinctly modulated by G protein subunits and are therefore hypothesized to be uniquely regulated by proteins that influence G protein signaling. Activator of G protein signaling 3 (AGS3) is a G protein modulator that binds Gαi subu...
متن کاملDecreased type VI adenylyl cyclase mRNA concentration
Objective: To address the effect of longstanding left ventricular (LV) hypertrophy and failure on LV adenylyl cyclase (AC) gene expression, mRNA concentrations of the main cardiac AC isoforms were measured in the non-infarcted area of LV from rats with 21 myocardial infarction (MI), without (H) or with (F) LV failure, and in control (C) rats. Basal, GTPand forskolin-stimulated Mg and 21 Mn -dep...
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ژورنال
عنوان ژورنال: Nature
سال: 1993
ISSN: 0028-0836,1476-4687
DOI: 10.1038/363679a0